Ethics are essential. I stick to my cartridges max point-blank range (MPBR), or often much less. What does that mean?

Accordingly, MPBR is the furthest distance your bullet can go without dropping out of your game animals kill zone and still have sufficient energy for a clean harvest. Example: Your game, a whitetail deer has a kill zone of say six to eight inches or so. If your bullet falls to the bottom of that kill zone at longer distances, then you are at your maximum range without adjusting your scope (MPBR).

In my case, using ballistic software, my MPBR often falls in the 250-to-300-yard range. Really, I have never had to shoot at game beyond 300 yards. 

It takes long-range practice with the cartridge and bullet you hunt with and know the effect of wind on your bullet. Hunting ethics are essential!

A book that I have in my hunting library below. 

If you are like me, experimentation is fun.

Good Hunting!