Frankly, a broadside heart lung shot on moose with either Nosler™ AccuBond™ bullet in 260 grain or 300 grain out of my 375 Ruger and its lights out.
ACCUBOND
From their website;
” Through an exclusive bonding process that eliminates voids in the bullet core, AccuBond® couples Nosler’s proven copper-alloy jacket with its special lead-alloy core. The result is a bullet that flies true, penetrates deep and retains its weight, without causing extensive barrel fouling”
left is the 260 grain and 300 grain on right
I have killed a bull moose several years back with the 260 grain AccuBond. The bullet mushroomed perfectly and lost little in weight. I have not tested the 300 grain AccuBond on Game however I expect similar results on shots under 100 yards. So why bother? The 260 grain has a Sectional Density of .264 and the 300 grain has an SD of .305. The difference is penetration of the 300 grain and will win hands down. So what makes Sectional Density so special? Read this article by Chuck Hawks at https://www.chuckhawks.com/sd.htm
At long range past 200 yards or short range high sectional density provides proven penetration on really big game and can reach the vitals and even provide an exit wound thus leaving a blood trail.
Good Hunting!